Identification of cyclic hexapeptides natural products with inhibitory potency against Mycobacterium tuberculosis.
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Academic Article
individual record
abstract
OBJECTIVE: Our aim was to identify natural products with anti-tubercular activity. RESULTS: A set of ~500 purified natural product compounds was screened for inhibition against the human pathogen Mycobacterium tuberculosis. A series of cyclic hexapeptides with anti-tubercular activity was identified. Five analogs from a set of sixteen closely related compounds were active, with minimum inhibitory concentrations ranging from 2.3 to 8.9M. Eleven structural analogs had no significant activity (MIC>20M) demonstrating structure activity relationship. Sequencing of resistant mutant isolates failed to identify changes accounting for the resistance phenotype.
authors
publication outlet
BMC Res Notes
author list (cited authors)
Singh, S. B., Odingo, J., Bailey, M. A., Sunde, B., Korkegian, A., O'Malley, T., ... Parish, T.
publication date
2018
publisher
Springer Nature
Publisher
keywords
- Anti-tubercular
- Microbial Sensitivity Tests
- Structure-Activity Relationship
- Humans
- Biological Products
- Antibiotic Resistance
- Antibacterial
- Natural Product
- Mycobacterium Tuberculosis
- Mycobacteria
- Antitubercular Agents
- Oligopeptides
altmetric score
4.3
citation count
1
PubMed ID
29954459
identifier
360705SE
Digital Object Identifier (DOI)
start page
416
volume
11
issue
1
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