Discovery of Antimicrobial Lipodepsipeptides Produced by a Serratia sp. within Mosquito Microbiomes. | Academic Article individual record
abstract

The Anopheles mosquito that harbors the Plasmodium parasite contains a microbiota that can influence both the vector and the parasite. In recent years, insect-associated microbes have highlighted the untapped potential of exploiting interspecies interactions to discover bioactive compounds. In this study, we report the discovery of nonribosomal lipodepsipeptides that are produced by a Serratia sp. within the midgut and salivary glands of Anopheles stephensi mosquitoes. The lipodepsipeptides, stephensiolidesA-K, have antibiotic activity and facilitate bacterial surface motility. Bioinformatic analyses indicate that the stephensiolides are ubiquitous in nature and are likely important for Serratia spp. colonization within mosquitoes, humans, and other ecological niches. Our results demonstrate the usefulness of probing insect-microbiome interactions, enhance our understanding of the chemical ecology within Anopheles mosquitoes, and provide a secondary-metabolite scaffold for further investigate of this complex relationship.

publication outlet

Chembiochem

author list (cited authors)
Ganley, J. G., Carr, G., Ioerger, T. R., Sacchettini, J. C., Clardy, J., & Derbyshire, E. R.
publication date
2018
publisher
Wiley Publisher
keywords
  • Mosquitoes
  • Plasmodium Falciparum
  • Depsipeptides
  • Serratia
  • Anti-Infective Agents
  • Animals
  • Humans
  • Natural Products
  • Malaria
  • Lipodepsipeptides
  • Lipopeptides
  • Hep G2 Cells
  • Bacteria
  • Mosquito Vectors
  • Microbiome
  • Anopheles
  • Malaria, Falciparum
altmetric score

20.88

citation count

17

PubMed ID
29700993
identifier
357242SE
Digital Object Identifier (DOI)
start page
1590
end page
1594
volume
19
issue
15
UN Sustainable Development Goals