Weight control and cancer preventive mechanisms: role of insulin growth factor-1-mediated signaling pathways. | Academic Article individual record
abstract

Overweight and obese not only increase the risk of cardiovascular disease and type-2 diabetes mellitus, but are also now known risk factors for a variety of cancers. Weight control, via dietary calorie restriction and/or exercise, has been demonstrated to be beneficial for cancer prevention in various experimental models, but the underlying mechanisms are still not well defined. Recent studies conducted in a mouse skin carcinogenesis model show that weight loss induced a significant reduction of the circulating levels of insulin growth factor (IGF)-1 and other hormones, including insulin and leptin, resulting in reduced IGF-1-dependent signaling pathways, i.e. Ras-MAPK proliferation and protein kinase B-phosphoinositide 3-kinase (Akt-PI3K) antiapoptosis. Selective targeting IGF-1 to Akt/mammalian target of rapamycin and AMP-activated protein kinase pathways, via negative energy balance, might inactivate cell cycle progression and ultimately suppress tumor development. This review highlights the current studies focused on the major role of reducing IGF-1-activated signaling via weight control as a potential cancer preventive mechanism.

authors
author list (cited authors)
Xie, L., & Wang, W.
publication date
2013
publisher
keywords
  • Insulin-Like Growth Factor I
  • Neoplasms
  • Body Weight
  • Disease Models, Animal
  • Signal Transduction
  • Mice
  • Humans
  • Animals
altmetric score

1.0

citation count

14

PubMed Central ID
23576795
identifier
347894SE
Digital Object Identifier (DOI)
start page
127
end page
132
volume
238
issue
2