Corepressor-dependent silencing of chromosomal regions encoding neuronal genes | Academic Article individual record
abstract

The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements.

authors
author list (cited authors)
Lunyak, V. V., Burgess, R., Prefontaine, G. G., Nelson, C., Sze, S. H., Chenoweth, J., ... Rosenfeld, M. G.
publication date
2002
published in
keywords
  • Computational Biology
  • Mice
  • Histone Deacetylases
  • Rats
  • Nav1.2 Voltage-gated Sodium Channel
  • Membrane Proteins
  • Transfection
  • Nerve Growth Factors
  • Gene Expression Regulation
  • Binding Sites
  • Chromosomes
  • Sodium Channels
  • CpG Islands
  • Chromosomal Proteins, Non-Histone
  • Neurons
  • Methyl-cpg-binding Protein 2
  • Models, Genetic
  • Intracellular Signaling Peptides And Proteins
  • Repressor Proteins
  • Transcription Factors
  • Promoter Regions, Genetic
  • Animals
  • Gene Silencing
  • DNA Methylation
  • DNA-Binding Proteins
  • Protein Structure, Tertiary
  • Carrier Proteins
  • Chromosomes, Human
  • Cell Line
  • Gene Expression Profiling
  • Nerve Tissue Proteins
  • Humans
altmetric score

6.0

citation count

362