Corepressor-dependent silencing of chromosomal regions encoding neuronal genes | Academic Article individual record

The molecular mechanisms by which central nervous system-specific genes are expressed only in the nervous system and repressed in other tissues remain a central issue in developmental and regulatory biology. Here, we report that the zinc-finger gene-specific repressor element RE-1 silencing transcription factor/neuronal restricted silencing factor (REST/NRSF) can mediate extraneuronal restriction by imposing either active repression via histone deacetylase recruitment or long-term gene silencing using a distinct functional complex. Silencing of neuronal-specific genes requires the recruitment of an associated corepressor, CoREST, that serves as a functional molecular beacon for the recruitment of molecular machinery that imposes silencing across a chromosomal interval, including transcriptional units that do not themselves contain REST/NRSF response elements.

author list (cited authors)
Lunyak, V. V., Burgess, R., Prefontaine, G. G., Nelson, C., Sze, S. H., Chenoweth, J., ... Rosenfeld, M. G.
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  • Computational Biology
  • Mice
  • Histone Deacetylases
  • Rats
  • Nav1.2 Voltage-gated Sodium Channel
  • Membrane Proteins
  • Transfection
  • Nerve Growth Factors
  • Gene Expression Regulation
  • Binding Sites
  • Chromosomes
  • Sodium Channels
  • CpG Islands
  • Chromosomal Proteins, Non-Histone
  • Neurons
  • Methyl-cpg-binding Protein 2
  • Models, Genetic
  • Intracellular Signaling Peptides And Proteins
  • Repressor Proteins
  • Transcription Factors
  • Promoter Regions, Genetic
  • Animals
  • Gene Silencing
  • DNA Methylation
  • DNA-Binding Proteins
  • Protein Structure, Tertiary
  • Carrier Proteins
  • Chromosomes, Human
  • Cell Line
  • Gene Expression Profiling
  • Nerve Tissue Proteins
  • Humans
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