A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro.
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Academic Article
individual record
abstract
We identified a novel 6-benzyl ether benzoxaborole with potent activity against Mycobacterium tuberculosis The compound had an MIC of 2 M in liquid medium. The compound was also able to prevent growth on solid medium at 0.8 M and was active against intracellular bacteria (50% inhibitory concentration [IC50] = 3.6 M) without cytotoxicity against eukaryotic cells (IC50 > 100 M). We isolated resistant mutants (MIC 100 M), which had mutations in Rv1683, Rv3068c, and Rv0047c.
authors
publication outlet
Antimicrob Agents Chemother
author list (cited authors)
Patel, N., O'Malley, T., Zhang, Y., Xia, Y. i., Sunde, B., Flint, L., ... Parish, T.
publication date
2017
publisher
American Society for Microbiology
Publisher
keywords
- Tuberculosis, Multidrug-Resistant
- Hep G2 Cells
- Humans
- Cell Line, Tumor
- Mycobacterium Tuberculosis
- Antitubercular Agents
- Tuberculosis, Pulmonary
- Microbial Sensitivity Tests
- Drug Resistance, Bacterial
- Antimicrobial
- Drug Resistance
- Antitubercular
altmetric score
11.0
citation count
9
identifier
295115SE
Digital Object Identifier (DOI)
start page
e01205
end page
e01217
volume
61
issue
9
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