A Novel 6-Benzyl Ether Benzoxaborole Is Active against Mycobacterium tuberculosis In Vitro | Academic Article individual record
abstract

We identified a novel 6-benzyl ether benzoxaborole with potent activity against Mycobacterium tuberculosis The compound had an MIC of 2 μM in liquid medium. The compound was also able to prevent growth on solid medium at 0.8 μM and was active against intracellular bacteria (50% inhibitory concentration [IC50] = 3.6 μM) without cytotoxicity against eukaryotic cells (IC50 > 100 μM). We isolated resistant mutants (MIC ≥ 100 μM), which had mutations in Rv1683, Rv3068c, and Rv0047c.

author list (cited authors)
Patel, N., O'Malley, T., Zhang, Y., Xia, Y. i., Sunde, B., Flint, L., ... Parish, T.
publication date
2017
publisher
keywords
  • Antitubercular
  • Antimicrobial
  • Drug Resistance