The main goal of our laboratory is to understand the molecular mechanisms of cardiac muscle dynamics in normal and diseased states. Particularly, our interests focus on the relationships between thin filament activation and crossbridge kinetics, and how the mechanotransduction signaling transmits to myofilament activation. We use multiple techniques, molecular, cellular, biochemistry, structural and biophysical, to obtain information on the fundamental regulatory mechanisms of cardiac muscle contraction.
- University of Cincinnati - (Cincinnati, Ohio, United States), Postdoctoral Training 1994
- Ph.D. in Biochemistry and Molecular Biology, Madurai Kamaraj University - (Madurai, Tamil Nadu, India) 1989
- M.Sc. in Biochemistry and Molecular Biology, Madurai Kamaraj University - (Madurai, Tamil Nadu, India) 1983
- B.Sc. in Chemistry, Madurai Kamaraj University - (Madurai, Tamil Nadu, India) 1980
- Chakraborty, S., Gurusamy, M., Zawieja, D. C., & Muthuchamy, M. (2013). Lymphatic Filariasis: Perspectives on Lymphatic Remodeling and Contractile Dysfunction in Filarial Disease Pathogenesis. Microcirculation (New York, N.Y. : 1994). 20(5), 349-364.
- Mamidi, R., Muthuchamy, M., & Chandra, M. (2013). Instability in the Central Region of Tropomyosin Modulates the Function of Its Overlapping Ends. Biophys J. 105(9), 2104-2113.
- Mamidi, R., Michael, J. J., Muthuchamy, M., & Chandra, M. (2013). Interplay between the overlapping ends of tropomyosin and the N terminus of cardiac troponin T affects tropomyosin states on actin. The FASEB Journal. 27(9), 3848-3859.
- Zhang, R., Taucer, A. I., Gashev, A. A., Muthuchamy, M., Zawieja, D. C., & Davis, M. J. (2013). Maximum shortening velocity of lymphatic muscle approaches that of striated muscle. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY. 305(10), H1494-H1507.
- Tangney, J. R., Chuang, J. S., Janssen, M. S., Krishnamurthy, A., Liao, P., Hoshijima, M., ... Omens, J. H. (2013). Novel Role for Vinculin in Ventricular Myocyte Mechanics and Dysfunction. Biophys J. 104(7), 1623-1633.