Modelling cholera epidemics: the role of waterways, human mobility and sanitation. | Academic Article individual record
abstract

We investigate the role of human mobility as a driver for long-range spreading of cholera infections, which primarily propagate through hydrologically controlled ecological corridors. Our aim is to build a spatially explicit model of a disease epidemic, which is relevant to both social and scientific issues. We present a two-layer network model that accounts for the interplay between epidemiological dynamics, hydrological transport and long-distance dissemination of the pathogen Vibrio cholerae owing to host movement, described here by means of a gravity-model approach. We test our model against epidemiological data recorded during the extensive cholera outbreak occurred in the KwaZulu-Natal province of South Africa during 2000-2001. We show that long-range human movement is fundamental in quantifying otherwise unexplained inter-catchment transport of V. cholerae, thus playing a key role in the formation of regional patterns of cholera epidemics. We also show quantitatively how heterogeneously distributed drinking water supplies and sanitation conditions may affect large-scale cholera transmission, and analyse the effects of different sanitation policies.

author list (cited authors)
Mari, L., Bertuzzo, E., Righetto, L., Casagrandi, R., Gatto, M., Rodriguez-Iturbe, I., & Rinaldo, A.
publication date
2012
publisher
published in
keywords
  • Epidemics
  • Sanitation
  • Cholera
  • Vibrio Cholerae
  • Population Dynamics
  • Water Microbiology
  • South Africa
  • Models, Theoretical
  • Humans
altmetric score

1.0

citation count

81