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Single pathogen challenge with agents of the bovine respiratory disease complex | Academic Article individual record

2015 Gershwinet al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Bovine respiratory disease complex (BRDC) is an important cause of mortality and morbidity in cattle; costing the dairy and beef industries millions of dollars annually, despite the use of vaccines and antibiotics. BRDC is caused by one or more of several viruses (bovine respiratory syncytial virus, bovine herpes type 1 also known as infectious bovine rhinotracheitis, and bovine viral diarrhea virus), which predispose animals to infection with one or more bacteria. These include: Pasteurella multocida, Mannheimia haemolytica, Mycoplasma bovis, and Histophilus somni. Some cattle appear to be more resistant to BRDC than others.We hypothesize that appropriate immune responses to these pathogens are subject to genetic control. To determine which genes are involved in the immune response to each of these pathogens it was first necessary to experimentally induce infection separately with each pathogen to document clinical and pathological responses in animals from which tissues were harvested for subsequent RNA sequencing. Herein these infections and animal responses are described.

author list (cited authors)
Gershwin, L. J., Van Eenennaam, A. L., Anderson, M. L., McEligot, H. A., Shao, M. X., Toaff-Rosenstein, R., ... Neibergs, S.
editor list (cited editors)
Harrod, K.
publication date
published in
PLoS ONE Journal
  • Immunohistochemistry
  • Herpesvirus 1, Bovine
  • Bovine Respiratory Disease Complex
  • Mycoplasma Bovis
  • Male
  • Disease Resistance
  • Respiratory Syncytial Virus, Bovine
  • Immunity, Humoral
  • Sequence Analysis, RNA
  • Pharynx
  • Lung
  • Bovine Respiratory Disease Complex Coordinated Agricultural Project Research Team
  • Pasteurella Multocida
  • Mannheimia Haemolytica
  • Animals
  • Cattle
  • Immune System
  • Ileum