A diet with lactosucrose supplementation ameliorates trinitrobenzene sulfonic acid-induced colitis in rats | Academic Article individual record

Chronic intestinal inflammation contributes to an increased risk of colon cancer. Lactosucrose (LS), a kind of functional trisaccharide, can modulate immunity and promote microbe growth. The aim of this study was to investigate the effect of LS on 2,4,6-trinitrobenzene sulfonic acid (TNBS) induced colitis in rats. Rats were randomly divided into four treatment groups: the normal group, TNBS group, LS group, and salicylazosulfapyridine (SASP) group for five weeks. LS supplementation ameliorated TNBS-induced colitis. LS supplementation increased IL-10 production and suppressed the secretion of IL-12 in the colon, as compared to the TNBS group. LS decreased the production of TLR-2 protein and nuclear NF-B p65 protein, as well as mRNA levels, as compared with colitic rats. These results indicate that chronic feeding of LS inhibited TNBS-induced chronic inflammation. LS has potential nutraceutical intervention to combat colitis.

author list (cited authors)
Zhou, Y., Ruan, Z., Zhou, X., Huang, X., Li, H., Wang, L., ... Yin, Y.
publication date
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  • Toll-Like Receptor 2
  • Random Allocation
  • Trinitrobenzenesulfonic Acid
  • Animals
  • Trisaccharides
  • Disease Models, Animal
  • Colon
  • Prebiotics
  • Rats, Sprague-Dawley
  • Female
  • Gastrointestinal Agents
  • Colitis
  • Anti-Inflammatory Agents, Non-Steroidal
  • Interleukin-12
  • Inflammatory Bowel Diseases
  • Interleukin-10
  • Specific Pathogen-Free Organisms
  • Transcription Factor RelA
  • Intestinal Mucosa
  • Sulfasalazine