GANGLIOSIDES, OR SIALIC-ACID, ANTAGONIZE ETHANOL INTOXICATION | Academic Article individual record
abstract

Because ethanol elicits a dose-dependent hydrolysis of brain sialogangliosides, we tested the possibility that injected gangliosides might antagonize intoxicating doses of ethanol. Clear anti-intoxication effects were seen at 24 hr post-injection of mixed mouse-brain gangliosides at 125-130 mg/kg, but not at lower or higher doses. Sleep time was reduced on the order of 50%, and roto-rod agility was significantly enhanced. Sialic acid (SA) similarly antagonized ethanol; however, the precursor of SA, N-acetyl-D-mannosamine, as well as ceramide and asialoganglioside did not.

author list (cited authors)
KLEMM, W. R., BOYLES, R., MATHEW, J., & CHERIAN, L.
publication date
1988
publisher
Elsevier bv Publisher
published in
Life Sci Journal
keywords
  • Sialic Acids
  • Mice
  • Animals
  • Kinetics
  • Ethanol
  • Alcohol Deterrents
  • Motor Activity
  • Dose-Response Relationship, Drug
  • Gangliosides
  • G(M1) Ganglioside
  • Sleep
  • N-acetylneuraminic Acid
citation count

34