ALPHA NORADRENERGIC AGONISTS PROMOTE CATALEPSY IN THE MOUSE | Academic Article individual record
abstract

Alpha adrenergic receptors are important in motor control. Adrenergic drugs reportedly modulate the catalepsy caused by other agents, such as opiates and neuroleptics. We tested a variety of adrenergic agonists and blockers in a nondrug, mouse model of catalepsy. A major cataleptic effect was produced by both alpha agonists, phenylephrine (0.5 to 3 mg/kg, IP) and clonidine (0.5 to 2 mg/kg), and this catalepsy was antagonized by pretreatment with both of the respective antagonists, phenoxybenzamine (alpha-1) and yohimbine (alpha-2) (p less than 0.0001). The mixed beta agonist, isoproterenol (2 mg/kg), appeared to have a minor cataleptic effect, and this was abolished by beta antagonist. Open-field locomotor scores during the same treatments revealed that catalepsy and hypokinesia are dissociable.

author list (cited authors)
SUKUL, N. C., CHERIAN, L., & KLEMM, W. R.
publication date
1988
publisher
Elsevier bv Publisher
published in
keywords
  • Adrenergic Alpha-Antagonists
  • Phenoxybenzamine
  • Catalepsy
  • Isoproterenol
  • Motor Activity
  • Yohimbine
  • Models, Biological
  • Phenylephrine
  • Mice
  • Timolol
  • Animals
  • Adrenergic Beta-Agonists
  • Adrenergic Alpha-Agonists
  • Clonidine
citation count

11