EXPERIMENTAL CATALEPSY - INFLUENCES OF CHOLINERGIC TRANSMISSION IN RESTRAINT-INDUCED CATALEPSY | Academic Article individual record
abstract

Possible cholinergic mechanisms in experimental catalepsy were evaluated by using the 'pinch-induced' model in mice. In control, saline-injected mice, the median number of attempts needed to achieve a criterion level of catalepsy was 6. All 3 dose levels of physostigmine reduced this median to about 2 trials; neostigmine did not significantly reduce the number of trials. Opposite effects were obtained with atropine, with which all 3 doses tested increased the number of trials needed to cause catalepsy, and at the higher doses (5 and 10 mg/kg) most of the mice (80%) became insusceptible: atropine methyl bromide had no such effects. Thus, this kind of catalepsy may be mediated by cholinergic mechanisms that are central and not peripheral.

author list (cited authors)
KLEMM, W. R.
publication date
1983
published in
EXPERIENTIA Journal
keywords
  • Restraint, Physical
  • Mice
  • Physostigmine
  • Acetylcholine
  • Catalepsy
  • Humans
  • Atropine Derivatives
  • Atropine
  • Animals
  • Dose-Response Relationship, Drug
  • Neostigmine
altmetric score

3.0

citation count

21