ETHANOL MAY STIMULATE OR INHIBIT (NA++K+)-ATPASE, DEPENDING UPON NA+ AND K+ CONCENTRATIONS | Academic Article individual record
abstract

The influence of varying the ratios of [Na+]/[K+] on the effects of alcohol (500 mg/dl) on brain (Na+ + K+)-ATPase, using a commercial porcine enzyme preparation, showed that, generally, activity was stimulated by ethanol when [Na+] less than [K+], but inhibited when [Na+] greater than [K+] (with sum kept constant at 150 mM). In addition, when [Na+]/[K+] was 15/90 mM, representative of normal intracellular levels, ethanol (500 mg/dl) stimulated the porcine enzyme, but inhibited it when [Na+]/[K+] was 144/6 mM, representative of normal extracellular levels. Similarly, in freshly prepared enzyme from highly purified rat brain synaptic membranes, ethanol (100, 300, and 450 mg/dl) stimulated when [Na+]/[K+] was 15/88 mM (representing intracellular levels), but inhibited when [Na+]/[K+] was 142/4 mM (extracellular levels).

author list (cited authors)
FOSTER, D. M., HUBER, M. D., & KLEMM, W. R.
publication date
1989
publisher
Elsevier bv Publisher
published in
ALCOHOL Journal
keywords
  • Brain
  • Osmolar Concentration
  • Animals
  • Ethanol
  • Cell Membrane
  • Microsomes
  • Sodium-Potassium-Exchanging ATPase
  • Potassium
  • Rats
  • Sodium
  • Swine
citation count

15