ALCOHOL, IN A SINGLE PHARMACOLOGICAL DOSE, DECREASES BRAIN GANGLIOSIDES | Academic Article individual record
abstract

Alcohol penetrates into cell membranes, fluidizing and disordering the microenvironment. Here we report that associated with the disordering is a reduction of the normal level of brain gangliosides of adult male rats. The maximum decrement occurred in all major classes of gangliosides at 4 to 8 hours after a single pharmacological dose (3 gm/kg, IP). Because gangliosides have diverse, important functions in cell membranes, this effect of alcohol might be a basis for some of its intoxicating and addicting properties.

author list (cited authors)
KLEMM, W. R., & FOSTER, D. M.
publication date
1986
publisher
Elsevier bv Publisher
published in
Life Sci Journal
keywords
  • Chromatography, Thin Layer
  • Gangliosides
  • Brain Chemistry
  • Rats, Inbred Strains
  • Rats
  • Male
  • Animals
  • Ethanol
citation count

37