Bondos, Sarah individual record
Assistant Professor

My laboratory works in two research areas. First, we are combining biophysical and genetic approaches to understand how proteins use unstructured regions to sense cellular information and respond by adjusting their function. We developed methods to purify Ultrabithorax, a full-length, active Hox transcription factor, and have used this unique opportunity to investigate the role of intramolecular regulatory interactions in tissue-specific protein regulation. Second, we discovered methods to self-assemble Ultrabithorax into robust, extensible materials that are biocompatible and provide unique opportunities for functionalization. These materials are being developed for use as biosensors and to pattern and instruct vascularization in tissue engineering scaffolds.

selected publications
Academic Articles36
  • Wilson, J. E., Wright, L. L., Martin, J. L., Haire, S. E., Ray, P. H., Painter, G. R., & Furman, P. A. (1996). Recombinant Human Immunodeficiency Virus Type 1 Reverse Transcriptase Is Heterogeneous. Journal of Acquired Immune Deficiency Syndromes and Human Retrovirology. 11(1), 20-30.
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Conference Papers10
  • Bondos, S. E. (2019). The critical role of intrinsic disorder in creating bioactive materials. Journal of biomolecular structure & dynamics. 37, 10-11.
  • Banerjee, S., Jordan, T. B., Fraser, K., Reimertz, J., Crone, E. E., Bunn, A. L., ... Bystroff, C. (2019). Computationally Guided Rational Design of LOO-GFP Biosensors and Biosensor Materials. Biophys J. 116(3), 443A-443A.
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  • Liu, Y., Huang, A., Booth, R., Mendes, G., Merchant, Z., Matthews, K. S., & Bondos, S. E. (2019). Evolution of the Intrinsically Disordered Activation Domain in a Hox Transcription Factor. Biophys J. 116(3), 178A-179A.
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  • Mendes, G. G., Howell, D. W., Tsai, S. P., Bayless, K. J., & Bondos, S. E. (2019). Engineering ubx-based materials to promote and guide neovascularization. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 40, 26.
  • Booth, R. M., Churion, K., Alvarez, A. J., Ramasamy, S., & Bondos, S. E. (2019). Dna delivery to cells by ultabithorax protein-based materials. Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium. 40, 571.
chaired theses and dissertations
First Name
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mailing address
Texas A&M Health Science Center; Molecular And Cellular Medicine; 1114 TAMUS
College Station, TX 77843-1114