My laboratory works in two research areas. First, we are combining biophysical and genetic approaches to understand how proteins use unstructured regions to sense cellular information and respond by adjusting their function. We developed methods to purify Ultrabithorax, a full-length, active Hox transcription factor, and have used this unique opportunity to investigate the role of intramolecular regulatory interactions in tissue-specific protein regulation. Second, we discovered methods to self-assemble Ultrabithorax into robust, extensible materials that are biocompatible and provide unique opportunities for functionalization. These materials are being developed for use as biosensors and to pattern and instruct vascularization in tissue engineering scaffolds.