The rescue of dentin matrix protein 1 (DMP1)-deficient tooth defects by the transgenic expression of dentin sialophosphoprotein (DSPP) indicates that DSPP is a downstream effector molecule of DMP1 in dentinogenesis | Academic Article individual record

Background: Previous in vitro studies indicated that dentin matrix protein 1 (DMP1) might regulate dentin sialophosphoprotein (DSPP) expression in odontoblasts. Results: Transgenic expression of DSPP rescued the tooth defects of Dmp1 knockout mice. Conclusion: DSPP is a downstream effector molecule of DMP1 in dentinogenesis. Significance: This study has identified the in vivo functional relationship of DMP1 and DSPP in dentinogenesis. © 2013 by The American Society for Biochemistry and Molecular Biology, Inc.

author list (cited authors)
Gibson, M. P., Zhu, Q., Wang, S., Liu, Q., Liu, Y., Wang, X., ... Lu, Y.
publication date
  • X-ray Microtomography
  • Animals
  • Gene Expression Regulation, Developmental
  • Rats
  • Cell Differentiation
  • Transcription Factors
  • Collagen Type I
  • Phosphoproteins
  • Mice
  • Dentinogenesis
  • Mandible
  • Sialoglycoproteins
  • Mice, Transgenic
  • Homeodomain Proteins
  • Biglycan
  • Tooth Abnormalities
  • Odontoblasts
  • Reverse Transcriptase Polymerase Chain Reaction
  • Tooth
  • Mice, Knockout
  • Extracellular Matrix Proteins
  • Immunohistochemistry
citation count