Pharmacokinetics after intravenous administration of flunixin meglumine in budgerigars (Melopsittacus undulatus) and Patagonian conures (Cyanoliseus patagonus). | Academic Article individual record
abstract

OBJECTIVE: To investigate the disposition kinetics of flunixin meglumine when administered IV to budgerigars (Melopsittacus undulatus) and Patagonian conures (Cyanoliseus patagonus). DESIGN: Prospective cohort study. ANIMALS: 8 adult Patagonian conures and 24 adult budgerigars. PROCEDURES: Injectable flunixin meglumine (50 mg/mL) was diluted to 10 and 1. 0 mg/mL and administered IV at a dose of 5.0 mg/kg (2.3 mg/lb) to Patagonian conures and budgerigars, respectively. RESULTS: In budgerigars, the elimination half-life was 0.72 hours and the mean residence time was 0.73 hours. In Patagonian conures, the elimination half-life was 0.91 hours and the mean residence time was 1.20 hours. The concentration of flunixin was below the assay's limit of quantification (0.5 μg/mL) at 3 and 6 hours in budgerigars and Patagonian conures, respectively. A single budgerigar developed adverse effects (lethargy and signs of depression) for approximately 15 minutes following drug administration. CONCLUSIONS AND CLINICAL RELEVANCE: The half-life of flunixin in Patagonian conures and budgerigars was short following IV administration; however, results of this study suggested that IV administration of injectable flunixin meglumine at 5.0 mg/kg resulted in plasma concentrations that could potentially be anti-inflammatory and analgesic in budgerigars and Patagonian conures.

author list (cited authors)
Musser, J., Heatley, J. J., & Phalen, D. N.
publication date
2013
keywords
  • Prostaglandin Antagonists
  • Psittaciformes
  • Clonixin
  • Area Under Curve
  • Species Specificity
  • Half-Life
  • Animals
citation count

7