CRF-like receptor SEB-3 in sex-common interneurons potentiates stress handling and reproductive drive in C. elegans. | Academic Article individual record
abstract

Environmental conditions can modulate innate behaviours. Although male Caenorhabditis elegans copulation can be perturbed in the presence of stress, the mechanisms underlying its decision to sustain copulation are unclear. Here we describe a mating interference assay, which quantifies the persistence of male C. elegans copulation in noxious blue light. We show that between copulations, the male escapes from blue light illumination at intensities over 370Wmm(-2). This response is attenuated in mutants with constitutive activation of the corticotropin-releasing factor receptor family homologue SEB-3. We show that activation of this receptor causes sex-common glutamatergic lumbar ganglion interneurons (LUA) to potentiate downstream male-specific reproduction circuits, allowing copulatory behaviours to partially override the light-induced escape responses in the male. SEB-3 activation in LUA also potentiates copulation during mild starvation. We suggest that SEB-3 activation allows C. elegans to acclimate to the environment and thus continue to execute innate behaviours even under non-optimal conditions.

publication outlet

Nat Commun

author list (cited authors)
Jee, C., Goncalves, J. F., LeBoeuf, B., & Garcia, L. R.
publication date
2016
publisher
Springer Nature Publisher
keywords
  • Male
  • Animals
  • Light
  • Caenorhabditis Elegans
  • Caenorhabditis Elegans Proteins
  • Escape Reaction
  • Stress, Physiological
  • Gene Expression Regulation
  • Sexual Behavior, Animal
  • Interneurons
  • Copulation
  • Receptors, G-Protein-Coupled
  • Hermaphroditic Organisms
  • Starvation
altmetric score

1.25

citation count

10

PubMed ID
27321013
identifier
133515SE
Digital Object Identifier (DOI)
start page
11957
volume
7
issue
1