Identification of the Product of Toxoflavin Lyase: Degradation via a Baeyer-Villiger Oxidation | Academic Article individual record
abstract

Toxoflavin (an azapteridine) is degraded to a single product by toxoflavin lyase (TflA) in a reaction dependent on reductant, Mn(II), and oxygen. The isolated product was fully characterized by NMR and MS and was identified as a triazine in which the pyrimidine ring was oxidatively degraded. A mechanism for toxoflavin degradation based on the identification of the enzymatic product and the recently determined crystal structure of toxoflavin lyase is proposed.

authors
author list (cited authors)
Philmus, B., Abdelwahed, S., Williams, H. J., Fenwick, M. K., Ealick, S. E., & Begley, T. P.
publication date
2012
keywords
  • Pyrimidinones
  • Triazines
  • Oxidation-Reduction
  • Molecular Structure
  • Lyases
  • Manganese
  • Oxygen
  • Models, Molecular
citation count

11