This laboratory is involved in studies focused on the effects of alcohol and cocaine on the developing brain. Animal model systems are used to address important questions, particularly related to fetal alcohol syndrome (FAS). One main focus is on factors that affect the risk and severity of fetal alcohol damage. For instance, our laboratory has found that the timing of the alcohol exposure, binge drinking, polydrug use and genetic factors all play a role in how much alcohol is dangerous to the developing fetus. Other aspects of our research investigates structure function relationships and neuroimmune system. The main focuses of our laboratory are now focused on the mechanism that causes fetal alcohol-induced cerebellar Purkinje cell death and identifying the specific damage caused by alcohol exposure during different discrete periods of brain development.
- Farnell, Y. Z., Allen, G. C., Neuendorff, N., West, J. R., Wei-Jung, A. C., & Earnest, D. J. (2009). Effects of neonatal alcohol exposure on vasoactive intestinal polypeptide neurons in the rat suprachiasmatic nucleus. ALCOHOL. 43(5), 387-396.
- Lee, Y., Rowe, J., Eskue, K., West, J. R., & Maier, S. E. (2008). Alcohol exposure on postnatal day 5 induces Purkinje cell loss and evidence of Purkinje cell degradation in lobule I of rat cerebellum. ALCOHOL. 42(4), 295-302.
- Farnell, Y. Z., Allen, G. C., Nahm, S., Neuendorff, N., West, J. R., Chen, W., & Earnest, D. J. (2008). Neonatal alcohol exposure differentially alters clock gene oscillations within the suprachiasmatic nucleus, cerebellum, and liver of adult rats. Alcohol Clin Exp Res. 32(3), 544-552.
- Parnell, S. E., Ramadoss, J., Delp, M. D., Ramsey, M. W., Chen, W., West, J. R., & Cudd, T. A. (2007). Chronic ethanol increases fetal cerebral blood flow specific to the ethanol-sensitive cerebellum under normoxaemic, hypercapnic and acidaemic conditions: ovine model. Experimental Physiology. 92(5), 933-943.
- Ramadoss, J., Lunde, E. R., Chen, W., West, J. R., & Cudd, T. A. (2007). Temporal vulnerability of fetal cerebellar Purkinje cells to chronic binge alcohol exposure: Ovine model. Alcohol Clin Exp Res. 31(10), 1738-1745.
- Livy, D. J., Teja, A., Behrendt, C. L., Rogers, N. L., Maier, S. E., & West, J. R. (2006). An examination of Purkinje cell numbers in the cerebellum of adult C57BL/6J mice exposed to alcohol very early in gestation.. Alcohol Clin Exp Res. 30(6), 229A-229A.
- Maeng, J., Neuendorff, N., West, J. R., Chen, W., & Earnest, D. J. (2006). Neonatal alcohol exposure alters anatomical components of the pathway for photic entrainment in adult rats.. Alcohol Clin Exp Res. 30(6), 298A-298A.
- Maeng, J., Neuendorff, N., West, J. R., Chen, W., & Earnest, D. J. (2006). Neonatal alcohol exposure alters the distribution of retinohypothalamic tract (RHT) fibers innervating the adult rat suprachiasmatic nucleus (SCN).. Alcohol Clin Exp Res. 30(6), 226A-226A.
- Ramadoss, J., Henderson, S., West, J. R., & Cudd, T. A. (2005). Binge alcohol exposure throughout gestation causes fetal Purkinje cell low in an ovine model system. Alcohol Clin Exp Res. 29(5), 89A-89A.
- Nahm, S., Farnell, Y. Z., Neuendorff, N., West, J. R., Chen, W., & Earnest, D. J. (2005). Effects of developmental alcohol exposure on vasoactive intestinal polypeptide and voltage-dependent calcium channel expression in rat SCN and cerebellum.. Alcohol Clin Exp Res. 29(5), 127A-127A.