Seismic inversion approach has been applied with a moderate success in some siliciclastic reservoirs in Oriente Basin characterized by their prominent lateral facies variations. Different types of facies with different geological and petrophysical characteristics can produce similar response in seismic velocities. Based on this fact, inversion results such as acoustic impedance, S-Impedance, Vp/Vs., Poisson ratio and other derived elastic parameters can be misinterpreted leading to locating faked prolific zones in areas where facies do not have enough quality to be considered productive. In order to avoid this problem, rock physics analysis is used to tie the seismic inversion results to the geological and petrophysical rock characteristics. The Sun model has been proven to characterize successfully the seismic response of carbonate and siliciclastics rocks and infer geological, depositional, diagenetical and petro physical characteristics from sonic logs and seismic data. Using the compressional frame flexibility factor (?k) and the shear frame flexibility factor (?u) derived from this model, it is possible to successfully correlate geological, depositional and diagenetical characteristics to the seismic response using well log and core data from a siliciclastic reservoir in Oriente Basin. ?k and ?s factors characterize the influence of pore structure on the variability of compressibility and shear sonic velocities respectively in rocks. For the studied siliciclastic reservoir, which presents a prominent lateral variation in facies related to its depositional process, different ranges of ?k factor values represent different kind of facies. Values of ?k between 2 and 6 in \"U\" sandstone reservoir are closely correlated to the best quality facies. According to the integrated rock physical, petrophysical and geological analysis in well locations, clean massive sandstones with fine to medium grain size and moderately sorting are represented by this ?k value interval. Using simultaneous inversion results, volumes of porosity and ?k are inverted from seismic data. Spatial distribution of the ?k values in the inverted volume correlates very well with a previous sedimentological and stratigraphic interpretation study using core data descriptions. Finally, using porosity and values of ?k, the discrimination of the best quality facies is performed. As a final result, new prospective zones are visualized taking into account the structural characteristics and facies distribution obtained by this integrated analysis.