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Sitcheran, Raquel Assistant Professor

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The goal of our research is to understand the molecular mechanisms that control NF-?B regulatory networks in the central nervous system (CNS). NF-?B is a ubiquitously expressed, evolutionarily conserved transcription factor that responds to a variety of signals and regulates fundamental processes, including cell growth and proliferation, inflammation, invasion and angiogenesis. Indeed, aberrant NF-?B activity or expression is associated with many cancers, as it can promote tumorigenesis, tumor progression and resistance to therapy. Our focus is on glioblastoma, a common and highly lethal CNS tumor that is very resistant to current treatment strategies.